Acute & Chronic Diarrhea · 11-Target Enteropathogen Panel

When Your Patient Can't Stop.

Bacterial, parasitic, viral, and C. difficile binary toxin coverage from a single stool specimen. Built for the patient whose diarrhea isn't getting better on its own.

At a glance
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Pathogens Identified
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C. diff Binary Toxin
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Hour TAT for results
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Stool Specimen
The clinical problem
Stool culture and O&P take days. Patients deteriorate in hours.

Traditional stool workup splits across culture, ova-and-parasite microscopy, EIA, and toxin testing — each with its own turnaround, sensitivity profile, and recollection risk. By the time results land, the patient has been empirically treated, hospitalized, or both.

Our 11-target GI panel resolves bacterial, parasitic, and viral enteropathogens — plus C. difficile binary toxin A/B — from one stool specimen in 24–48 hours.

By the Numbers

The clinical weight behind this panel.

Industry statistics from public-health bodies and peer-reviewed literature — context for why this testing matters.

179M
episodes of acute gastroenteritis in the U.S. annually
Source · CDC FoodNet
1 in 6
Americans gets sick from contaminated food each year

48 million illnesses, 128,000 hospitalizations, 3,000 deaths.

Source · CDC
20–40×
higher pathogen detection vs. conventional stool culture

Multiplex PCR closes the diagnostic gap left by traditional methods.

Source · IDSA Guideline
462K
U.S. C. difficile infections per year — 29K deaths

Hypervirulent NAP1/BI/027 strains demand rapid identification.

Source · CDC

Figures reflect publicly reported epidemiology and clinical literature for context only. They are not performance claims for the Chaseville Labs assay. See individual citations from the U.S. Centers for Disease Control and Prevention, World Health Organization, National Institutes of Health, and peer-reviewed journals.

What This Panel Diagnoses

Conditions, syndromes & infections covered.

The clinical scenarios where this panel is the right call — built around the differential your providers are actually working through.

Bacterial Food Poisoning & Intestinal Infections

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Salmonellosis (Salmonella spp.)

Severe diarrhea, fever, and abdominal cramps from contaminated poultry, eggs, or produce.

Clinical Impact ·Rapid detection prevents unnecessary antibiotics — healthy adults rarely need them, but infants and the elderly do.
Campylobacteriosis (Campylobacter spp.)

One of the most common causes of bacterial diarrhea worldwide.

Clinical Impact ·Rapid identification supports early macrolide therapy (azithromycin) to shorten the illness.
Yersiniosis (Yersinia enterocolitica)

Mimics acute appendicitis with severe right-sided abdominal pain.

Clinical Impact ·Quick detection can prevent unnecessary appendectomies.
Vibrio Infections (V. parahaemolyticus, V. vulnificus, V. cholerae)

V. cholerae causes cholera — life-threatening watery diarrhea requiring immediate fluid replacement. V. vulnificus can cause deadly sepsis, especially in patients with liver disease.

Clinical Impact ·Critical for shellfish-exposure histories and coastal practices.
Plesiomonas Infection (Plesiomonas shigelloides)

Often contracted from contaminated water or raw shellfish, causing severe dehydration.

Diarrheagenic E. coli & Dysentery

4
Bacillary Dysentery (Shigella / EIEC)

Bloody diarrhea, severe cramping, and high fever. Highly contagious.

Clinical Impact ·Rapid detection triggers immediate isolation to prevent outbreaks in schools, daycares, and long-term care.
Shiga Toxin–Producing E. coli (STEC) — HUS Risk

STEC can cause Hemolytic Uremic Syndrome (HUS), a deadly condition that destroys red blood cells and causes kidney failure.

Clinical Impact ·Critical treatment impact: antibiotics in STEC infection can dramatically increase toxin release and trigger kidney failure. This test tells doctors exactly when NOT to give antibiotics.
Traveler's Diarrhea (ETEC, EAEC)

The leading cause of diarrhea in travelers returning from developing regions.

Infantile Diarrhea (EPEC)

A major cause of severe, dehydrating diarrhea in infants and young children — especially in daycare settings.

Hospital-Acquired & Antibiotic-Induced Colitis

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Pseudomembranous Colitis (C. difficile Toxins A, B, Binary)

Typically occurs after broad-spectrum antibiotics wipe out protective gut flora, causing severe, life-threatening colitis.

Clinical Impact ·Binary toxin detection flags hypervirulent strains requiring aggressive targeted therapy — oral vancomycin or fidaxomicin — and strict contact isolation.

Viral Gastroenteritis ("Stomach Flu")

3
Norovirus (GI / GII) & Sapovirus

Leading causes of non-bacterial gastroenteritis outbreaks worldwide — cruise ships, schools, and nursing homes.

Clinical Impact ·Rapid ID enables outbreak containment and avoids unnecessary antibiotic use.
Rotavirus A & Astrovirus

Major causes of severe, dehydrating diarrhea in infants and young children worldwide.

Adenovirus F40/41

A gut-targeting viral strain causing prolonged diarrhea, mostly in children.

Clinical Impact ·Because these are viral, antibiotics will not work — confirmation lets the team focus on hydration and stop empirical antibiotics immediately.

Parasitic Infections (Protozoan Diseases)

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Giardiasis (Giardia lamblia)

Chronic, foul-smelling diarrhea, bloating, and weight loss.

Clinical Impact ·Targeted antiparasitic therapy with metronidazole or tinidazole.
Cryptosporidiosis (Cryptosporidium spp.)

Watery diarrhea — highly dangerous and potentially life-threatening for immunocompromised patients (HIV/AIDS, chemotherapy, transplant).

Amebiasis / Amebic Dysentery (Entamoeba histolytica)

Bloody stool from a parasite that, if untreated, can travel through the bloodstream and cause dangerous liver abscesses.

Cyclosporiasis (Cyclospora cayetanensis)

Often linked to contaminated fresh produce (berries, lettuce), causing prolonged, relapsing diarrhea for weeks.

Clinical Impact ·Requires specific therapy with trimethoprim-sulfamethoxazole (TMP-SMX).
Complete Target List

11 targets, resolved from a single specimen.

Each organism below is reported individually as Detected, Not Detected, or Inconclusive — grouped here by pathogen class for clinical scanability.

Bacteria

7 targets
Vibrio vulnificusSalmonella spp.Campylobacter spp.STEC (Shiga toxin-producing E. coli)Shigella / EIECYersinia enterocoliticaC. difficile binary toxin A/B

Parasitic

3 targets
Giardia lambliaEntamoeba histolyticaCryptosporidium spp.

Viral

1 target
Norovirus GI/GII
Why Molecular

Culture was built for a different century.

Multiplex real-time PCR resolves what culture and rapid antigen miss — fastidious organisms, polymicrobial infections, viruses, and resistance markers — from a single specimen.

Conventional
The Old Way

Culture & rapid antigen

  • 3–5 days
    Patient empirically treated before any answer arrives
  • Misses fastidious & viral organisms
    No growth ≠ no infection
  • Single-organism bias
    Polymicrobial infections under-reported
  • No resistance data
    Susceptibilities arrive a day later, if at all
  • Specimen-quality dependent
    Pre-treated patients culture negative
Multiplex PCR
The CRL Way

GI Panel on Bio-Rad CFX384

  • 24–48 hours
    Most reports back the next clinical day
  • 11 targets, one run
    Bacterial, viral, fungal, and parasitic in a single multiplex
  • Detects what culture can't
    Fastidious organisms, viruses, and polymicrobial infections, all reported individually
  • Validated LDT
    CLIA-certified, internally controlled, per-target Detected / Not Detected reporting
Primary Specimen
Stool, Copan E-swab
Collection Container
Copan Diagnostics ESwab™ Patented Sample Collection and Delivery System
Volume
≥1 g stool
Storage
2–8°C up to 96 hours
Transport
Pre-paid FedEx Priority Overnight
Stability
Validated per storage condition
Chain of Custody
Barcoded, temperature-logged in transit
Result Format

Per-target results, with clinical context.

Every analyte is reported individually as Detected, Not Detected, or Inconclusive. What a Detected result means clinically depends on which category the target falls into:

Bacteria
Vibrio vulnificusSalmonella spp.Campylobacter spp.STEC (Shiga toxin-producing E. coli)Shigella / EIECYersinia enterocoliticaC. difficile binary toxin A/B
If Detected

Bacterial detections drive isolation precautions, public-health reporting (Salmonella, Shigella, STEC), and targeted therapy. C. difficile toxin positivity confirms CDI in symptomatic patients; binary toxin raises concern for hypervirulent strains.

Parasitic
Giardia lambliaEntamoeba histolyticaCryptosporidium spp.
If Detected

Protozoan detections often explain prolonged or travel-associated diarrhea and respond to species-specific therapy (metronidazole/tinidazole, nitazoxanide, TMP-SMX) rather than empiric antibacterials.

Viral
Norovirus GI/GII
If Detected

Viral detections support supportive care and infection-control measures rather than antimicrobials. Norovirus and rotavirus drive outbreak investigation in congregate settings.

Qualitative multiplex real-time PCR (Bio-Rad CFX384)
Turnaround: 24–48 hours