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Complicated & Recurrent UTI · 10-Target Molecular Panel

Identify the Pathogen. Pick the Right Drug. Same Day.

Built for the patient your culture keeps missing. 10 evidence-curated uropathogens — including fungal organisms culture routinely misses — from a single specimen.

At a glance
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Targets Identified
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Candida Species
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Bacterial Uropathogens
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Hour TAT for results
The clinical problem
Culture-negative does not mean infection-negative.

Standard urine culture misses up to a third of true uropathogens — fastidious organisms, fungal species, polymicrobial infections, and patients already started on empirical antibiotics. Recurrent UTI patients pay for that miss with months of failed therapy.

Our UTI panel resolves all 10 targets from a single tube in 24–48 hours — so the first report your stewardship pharmacist sees already has the organism-level answer.

By the Numbers

The clinical weight behind this panel.

Industry statistics from public-health bodies and peer-reviewed literature — context for why this testing matters.

~60%
of women experience a UTI in their lifetime

One of the most common bacterial infections in outpatient medicine.

Source · NIDDK
8.1M
U.S. ambulatory visits for UTI annually

Driving a significant share of empiric antibiotic prescribing.

Source · CDC / AHRQ
30–40%
of uncomplicated UTIs recur within 6 months

Pathogen-level identification reshapes recurrence workups.

Source · AUA Guideline
>25%
E. coli resistance to TMP-SMX in many U.S. regions

Why empiric therapy increasingly misses the target.

Source · CDC AR Threats

Figures reflect publicly reported epidemiology and clinical literature for context only. They are not performance claims for the Chaseville Labs assay. See individual citations from the U.S. Centers for Disease Control and Prevention, World Health Organization, National Institutes of Health, and peer-reviewed journals.

What This Panel Diagnoses

Conditions, syndromes & infections covered.

The clinical scenarios where this panel is the right call — built around the differential your providers are actually working through.

Complicated & Recurrent UTI

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Recurrent UTI (rUTI)

≥2 infections in 6 months or ≥3 in 12 months — culture often misses the shifting or persistent organism driving recurrence.

Clinical Impact ·Identifies fastidious organisms and polymicrobial patterns that empirical therapy keeps missing.
Complicated UTI

Diabetes, pregnancy, structural anomalies, kidney transplant, or immunocompromise where standard culture under-performs.

Clinical Impact ·Per-target Detected / Not Detected reporting supports narrow, targeted antibiotic choice from day one.
Catheter-associated UTI (CAUTI)

Polymicrobial and biofilm-driven infections — the most common healthcare-associated infection.

Clinical Impact ·Resolves multiple organisms in one run so therapy isn't aimed at the loudest grower while the real driver is missed.
Culture-negative pyuria

Symptomatic patient with negative urine culture — the classic frustrated rUTI patient.

Clinical Impact ·PCR resolves fastidious organisms (Ureaplasma, Aerococcus, anaerobes) and yeasts that culture never grew.

Severe & Healthcare-Associated UTI

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Pyelonephritis & urosepsis

Kidney infection and bloodstream extension — every hour of inappropriate empirical therapy raises mortality.

Clinical Impact ·Same-day organism ID supports IV antibiotic narrowing and shortens length of stay.
Multi-drug resistant (MDR) UTI

ESBL, CRE, MRSA, and VRE uropathogens — common in long-term care and post-instrumentation patients.

Clinical Impact ·Auto-reflexes into the ABR panel — 12 resistance genes returned alongside the organism ID.
Candiduria in immunocompromised hosts

Species-level Candida ID — C. glabrata, C. krusei, and C. auris are intrinsically less susceptible to fluconazole.

Clinical Impact ·Drives correct antifungal selection (echinocandin vs. fluconazole) the first time.
Pregnancy-related UTI & asymptomatic bacteriuria

Untreated infection in pregnancy raises preterm labor and pyelonephritis risk — broad coverage matters.

Complete Target List

10 targets, resolved from a single specimen.

Each organism below is reported individually as Detected, Not Detected, or Inconclusive — grouped here by pathogen class for clinical scanability.

Bacteria

12 targets
Escherichia coliKlebsiella pneumoniaeProteus mirabilisEnterococcus faecalisPseudomonas aeruginosaStaphylococcus aureusStreptococcus agalactiae (GBS)Providencia stuartiiMorganella morganiiEnterococcus faeciumCitrobacter freundiiAerococcus urinae

Fungi

3 targets
Candida albicansCandida glabrataCandida tropicalis
Why These 15 Organisms

Evidence-curated for the patients who fail empirical therapy.

Every target on this panel is here for a documented clinical reason — drawn from the geriatric, long-term-care, catheter-associated, and recurrent-UTI literature. No filler organisms, no marketing additions.

  1. 01

    Escherichia coli

    The most frequent uropathogen overall, though less dominant in institutionalized elderly patients than in the general public.

  2. 02

    Klebsiella pneumoniae

    Highly prevalent in long-term care settings and notoriously prone to multi-drug resistance.

  3. 03

    Proteus mirabilis

    Spikes heavily in geriatric populations; intimately linked with incontinence, catheter biofilms, and struvite kidney stones.

  4. 04

    Enterococcus faecalis

    A primary Gram-positive driver of healthcare- and device-associated UTIs in older adults.

  5. 05

    Pseudomonas aeruginosa

    Common in patients with a history of frequent antibiotic use or indwelling medical devices.

  6. 06

    Staphylococcus aureus

    Critical to catch — its presence in geriatric urine strongly signals possible bloodborne infection or MRSA seeding.

  7. 07

    Streptococcus agalactiae (GBS)

    Famous in pregnancy, but highly opportunistic in diabetic or bedridden elderly patients.

  8. 08

    Candida albicans

    Fungal tracking is useful here because chronic antibiotic exposure frequently leads to bladder colonization.

  9. 09

    Candida glabrata

    The second most common urinary fungus — vital to differentiate because it is often resistant to standard fluconazole.

  10. 10

    Candida tropicalis

    Covers the remaining major non-albicans fungal threat in this population.

Why Molecular

Culture was built for a different century.

Multiplex real-time PCR resolves what culture and rapid antigen miss — fastidious organisms, polymicrobial infections, viruses, and resistance markers — from a single specimen.

Conventional
The Old Way

Culture & rapid antigen

  • 3–5 days
    Patient empirically treated before any answer arrives
  • Misses fastidious & viral organisms
    No growth ≠ no infection
  • Single-organism bias
    Polymicrobial infections under-reported
  • No resistance data
    Susceptibilities arrive a day later, if at all
  • Specimen-quality dependent
    Pre-treated patients culture negative
Multiplex PCR
The CRL Way

UTI Panel on Bio-Rad CFX384

  • 24–48 hours
    Most reports back the next clinical day
  • 10 targets, one run
    Bacterial, viral, fungal, and parasitic in a single multiplex
  • Detects what culture can't
    Fastidious organisms, viruses, and polymicrobial infections, all reported individually
  • Validated LDT
    CLIA-certified, internally controlled, per-target Detected / Not Detected reporting
Primary Specimen
Urine, urethral swab
Collection Container
Sterile urine cup or boric acid preservative tube
Volume
5–10 mL
Storage
2–8°C up to 48 hours
Transport
Pre-paid FedEx Priority Overnight
Stability
Validated per storage condition
Chain of Custody
Barcoded, temperature-logged in transit
Result Format

Per-target results, with clinical context.

Every analyte is reported individually as Detected, Not Detected, or Inconclusive. What a Detected result means clinically depends on which category the target falls into:

Bacteria
Escherichia coliKlebsiella pneumoniaeProteus mirabilisEnterococcus faecalisPseudomonas aeruginosaStaphylococcus aureusStreptococcus agalactiae (GBS)Providencia stuartiiMorganella morganiiEnterococcus faeciumCitrobacter freundiiAerococcus urinae
If Detected

Gram-negative rods (E. coli, Klebsiella, Proteus) dominate uncomplicated UTI and direct first-line therapy. Pseudomonas, Acinetobacter, Enterococcus, and Staph aureus typically signal complicated, catheter-associated, or healthcare-acquired infection and warrant broader coverage and source control.

Fungi
Candida albicansCandida glabrataCandida tropicalis
If Detected

Candiduria in a symptomatic, immunocompromised, or catheterized patient may represent true infection rather than colonization. C. glabrata, C. krusei, and C. auris are intrinsically less susceptible to fluconazole and should prompt species-directed antifungal selection.

Qualitative multiplex real-time PCR (Bio-Rad CFX384)
Turnaround: 24–48 hours